Yao xue xue bao = Acta pharmaceutica Sinica 2005-06-01

The chemical constituents of Ligularia pleurocaulis.

Mian Zhang, Chao-Feng Zhang, Zheng-Tao Wang

Index: Yao Xue Xue Bao 40(6) , 529-32, (2005)

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Abstract

To study the chemical constituents of the underground part of Ligularia pleurocaulis (Franch.) Hand-Mazz.The dried roots and rhizomes of L. pleurocaulis were extracted with methanol. Isolation and purification were performed by silica gel column chromatography and recrystallization etc. Structures of the pure compounds were established on basis of spectral analysis.Twelve compounds were obtained from L. pleurocaulis, they were 6-angeloyloxy-furanoligularenone (1), 2-oxo-3-hydroxy-eremophila-1(10),3,7(11),8-tetraen-8,12-olide (2), tiglic acid (3), oleanolic acid (4), lupeol (5), beta-sitosterol (6), daucosterol (7), caffeic acid (8), emodin (9), 7-methoxy-coumarin (10), ferulic acid (11) and 4-hydroxy-2,5-dimethoxy-benzaldehyde (12).Compound 1 is a new eremophilane and compound 2 is a new natural compound. All above compounds were obtained for the first time from L. pleurocaulis.