Tetrahedron letters

N-methoxydiacetamide: A new selective acetylating agent

Y Kikugawa, K Mitsui, T Sakamoto, M Kawase…

Index: Kikugawa, Yasuo; Mitsui, Kimiyo; Sakamoto, Takeshi; Kawase, Masami; Tamiya, Hiroshi Tetrahedron Letters, 1990 , vol. 31, # 2 p. 243 - 246

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Citation Number: 40

Abstract

Summary: A simple and efficient method for the direct chemoselective acetylation of primary amines in the presence of alcohols or secondary amines using a new reagent N-methoxydiacetamide is described. ... Acetylation is one of the most basic reactions in synthetic organic chemistry and selective acetylation of amino groups in the presence of other functional groups which can be acetylated by acetic anhydride has great practi cal utility.' We wish to report here a new ...