Journal of Organic Chemistry 2012-07-06

Difluoro(trimethylsilyl)acetonitrile: synthesis and fluoroalkylation reactions.

Mikhail D Kosobokov, Alexander D Dilman, Vitalij V Levin, Marina I Struchkova

Index: J. Org. Chem. 77(13) , 5850-5, (2012)

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Abstract

A new silicon reagent, difluoro(trimethylsilyl)acetonitrile, was prepared by insertion of difluorocarbene into silyl cyanide. The obtained silane served as a good cyanodifluoromethylating reagent toward aldehydes, N-tosylimines, N-alkylimines, and enamines under basic or acidic conditions.