CuI/8??Hydroxyquinalidine Promoted N??Arylation of Indole and Azoles

X Yang, H Xing, Y Zhang, Y Lai, Y Zhang…

Index: Zhang, Yihua; Yang, Xinye; Xing, Hui; Zhang, Ye; Lai, Yisheng; Jiang, Yongwen; Ma, Dawei Chinese Journal of Chemistry, 2012 , vol. 30, # 4 p. 875 - 880

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Citation Number: 13

Abstract

Abstract An efficient catalytic system of CuI/8-hydroxyquinalidine was developed for the coupling of aryl iodides and indole as well as some azoles. The reaction could be carried out at 90 C under the condition of relatively low catalyst loading, affording various N- arylindoles and N-aryl azoles in good yields. The functionalized and hindered aryl iodides were suitable substrates for this transformation.