Drug and Chemical Toxicology 2011-10-01

Investigation on acute toxicity and behavioral changes in Channa punctatus (Bloch) due to organophosphate pesticide profenofos.

Atindra Kumar Pandey, N S Nagpure, Sunil P Trivedi, Ravindra Kumar, Basdeo Kushwaha, Wazir S Lakra

Index: Drug Chem. Toxicol. 34(4) , 424-8, (2011)

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Abstract

Acute toxicity of an organophosphate pesticide profenofos (O-4-bromo-2- chlorophenyl-O-ethyl S-propyl phosphorothioate) to freshwater fish, Channa punctatus (Bloch), was studied in a static bioassay. Estimated 96-hour LC(50) of profenofos was found to be 2.68 μgL(-1). On the basis of the obtained LC(50) values for 96-hour exposure intervals, profenofos can be rated as highly toxic to C. punctatus. Fish exposed to profenofos showed hyper excitability, discoloration, erratic swimming, and secretion of excess amounts of mucus on the body and gills with eventual exhaustion and death.