Synthesis

Synthesis of 2-Aminoindole-3-carboxylic Acid Derivatives by the Copper (I) Iodide Catalyzed Reaction of N-(2-Iodophenyl) formamides with Malononitrile or …

K Kobayashi, T Komatsu, Y Yokoi, H Konishi

Index: Kobayashi, Kazuhiro; Komatsu, Toshihide; Yokoi, Yuki; Konishi, Hisatoshi Synthesis, 2011 , # 5 p. 764 - 768

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Citation Number: 3

Abstract

Abstract An efficient method for the synthesis of 2-aminoindole-3-carbonitriles and 2- aminoindole-3-carboxylates by the reaction of N-(2-iodophenyl) formamides with malononitrile and cyanoacetates, respectively, in the presence of a catalytic amount of copper (I) iodide using potassium carbonate as a base is reported.