The first total synthesis of the biologically significant bis-indole alkaloid dragmacidin D (5) has been achieved. Thermal and electronic modulation provides the key for a series of palladium-catalyzed Suzuki cross-coupling reactions that furnished the core structure of the complex guanidine-and aminoimidazole-containing dragmacidins. Following this crucial sequence, a succession of meticulously controlled final events was developed leading to ...
![6-Bromo-1-[(4-methylphenyl)sulfonyl]-1H-indole Structure](https://image.chemsrc.com/caspic/461/189265-99-4.png)
