7-Alkyl-and 7-Cycloalkyl-5-aryl-pyrrolo [2, 3-d] pyrimidines—Potent Inhibitors of the Tyrosine Kinase c-Src

…, J Green, M Missbach, M Šuša, E Altmann

Index: Widler, Leo; Green, Jonathan; Missbach, Martin; Susa, Mira; Altmann, Eva Bioorganic and Medicinal Chemistry Letters, 2001 , vol. 11, # 6 p. 849 - 852

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Citation Number: 58

Abstract

7-Substituted-5-aryl-pyrrolo [2, 3-d] pyrimidines have been prepared starting from α- bromoacetophenones. These compounds represent a novel class of potent inhibitors of the tyrosine kinase pp60c-Src with good specificity towards other tyrosine kinases (EGF-R, v- Abl).

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