Organic Letters 2011-08-05

Ligand effects on Negishi couplings of alkenyl halides.

Arkady Krasovskiy, Bruce H Lipshutz

Index: Org. Lett. 13(15) , 3818-21, (2011)

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Abstract

Negishi couplings at olefinic centers do not always occur with the anticipated maintenance of stereochemistry. The source of erosion has been traced to the ligand, and a modified method has been developed that solves the stereochemical issue and significantly improves yields of Negishi couplings in general.© 2011 American Chemical Society