… , antihypoxics, and inducers of the hepatic monooxygenase system. IX. Synthesis and search for inducers of the liver cytochrome P-450-dependent monooxygenase …

AA Bakibaev, RR Akhmedzhanov, AY Yagovkin…

Index: Bakibaev, A. A.; Akhmedzhanov, R. R.; Yagovkin, A. Yu.; Novozheeva, T. P.; Filimonov, V. D.; Saratikov, A. S. Pharmaceutical Chemistry Journal, 1993 , vol. 27, # 6 p. 401 - 406 Khimiko-Farmatsevticheskii Zhurnal, 1993 , vol. 27, # 6 p. 29 - 33

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Citation Number: 10

Abstract

Heterocyclic compounds based on carbamide fragments generally have wide spectra of biological activity. Some members of this class of compounds have been used clinically as tranquilizers (eg, mebicar)[6] and anticonvulsants (benzonal, diphenin)[7]. Phenobarbital, benzene, and diphenin are powerful inducers of the microsomal oxidation and metabolism of xenobiotics [i0, 12, 13]. However, there have thus far been no systematic and directed ...