e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521

Structure–activity studies on splitomicin derivatives as sirtuin inhibitors and computational prediction of binding mode

RC Neugebauer, U Uchiechowska…

Index: Fries; Schimmelschmidt Justus Liebigs Annalen der Chemie, 1930 , vol. 484, p. 245,271

Full Text: HTML

Citation Number: 132

Abstract

... Volume: Page: ... Thus, we initially prepared a series of β-aryl-8-bromosplitomicins 5a−p and 5r by the acid-catalyzed cyclization of cinnamic acids 7a and 7c−e with β-naphthols 6a−h (see Scheme 1 and Table 1). Similarly, the use of acrylic acid (7b) instead of a ...

1,3-Dibromonaphthalene-2-ol Structure

1,3-Dibromonaph...

~%

2-Bromo-3-methoxynaphthalene Structure

2-Bromo-3-metho...

1,1,3,4,6,7-hexabromo-3,4,6,7-tetrahydro-1H-naphthalen-2-one Structure

1,1,3,4,6,7-hex...

~%

2-Bromo-3-methoxynaphthalene Structure

2-Bromo-3-metho...

2-Naphthol Structure

~%

2-Bromo-3-methoxynaphthalene Structure

2-Bromo-3-metho...

3-Bromo-2-naphthol Structure

3-Bromo-2-naphthol

Dimethyl sulfate Structure

Dimethyl sulfate

~%

2-Bromo-3-methoxynaphthalene Structure

2-Bromo-3-metho...

1,3-Dibromonaphthalene-2-ol Structure

1,3-Dibromonaph...

~%

3-bromonaphthalene-1,2-dione Structure

3-bromonaphthal...

1,1-dibromo-1H-naphthalen-2-one Structure

1,1-dibromo-1H-...

~%

3-bromonaphthalene-1,2-dione Structure

3-bromonaphthal...

1,1,3,4,6,7-hexabromo-3,4,6,7-tetrahydro-1H-naphthalen-2-one Structure

1,1,3,4,6,7-hex...

~%

3-bromonaphthalene-1,2-dione Structure

3-bromonaphthal...

2-Naphthol Structure

~%

3-bromonaphthalene-1,2-dione Structure

3-bromonaphthal...

1,1-dibromo-1H-naphthalen-2-one Structure

1,1-dibromo-1H-...

~%

2-Bromo-3-methoxynaphthalene Structure

2-Bromo-3-metho...

1,1,3-tribromo-1H-naphthalen-2-one Structure

1,1,3-tribromo-...

~%

molecular iodine Structure

molecular iodine

1,1,3,6-tetrabromonaphthalen-2-(1H)-one Structure

1,1,3,6-tetrabr...

~%

molecular iodine Structure

molecular iodine

Ethanol Structure

4-Phenylamino-3-brom-1,2-naphthochinon Structure

4-Phenylamino-3...

Structure

~%

2-anilino-4-phenylimino-naphthalen-1-one Structure

2-anilino-4-phe...

3-bromonaphthalene-1,2-dione Structure

3-bromonaphthal...

~%

1,4-Naphthalenedione,2-bromo-3-hydroxy- Structure

1,4-Naphthalene...

1,3-Dibromonaphthalene-2-ol Structure

1,3-Dibromonaph...

~%

1,4-Naphthalenedione,2-bromo-3-hydroxy- Structure

1,4-Naphthalene...

1,1-dibromo-1H-naphthalen-2-one Structure

1,1-dibromo-1H-...

~%

1,4-Naphthalenedione,2-bromo-3-hydroxy- Structure

1,4-Naphthalene...

1,1,3,4,6,7-hexabromo-3,4,6,7-tetrahydro-1H-naphthalen-2-one Structure

1,1,3,4,6,7-hex...

~%

1,4-Naphthalenedione,2-bromo-3-hydroxy- Structure

1,4-Naphthalene...

2-Naphthol Structure

~%

1,4-Naphthalenedione,2-bromo-3-hydroxy- Structure

1,4-Naphthalene...

N/A Structure

~%

6-Bromo-1-chloro-2-naphthol Structure

6-Bromo-1-chlor...

N/A Structure

Hydrogen bromide Structure

Hydrogen bromide

acetic acid Structure

~%

6-Bromo-1-chloro-2-naphthol Structure

6-Bromo-1-chlor...

Hydrochloric acid Structure

Hydrochloric acid

1-bromo-1-chloro-1H-naphthalen-2-one Structure

1-bromo-1-chlor...

acetic acid Structure

~%

6-Bromo-1-chloro-2-naphthol Structure

6-Bromo-1-chlor...

1-bromo-1-chloro-1H-naphthalen-2-one Structure

1-bromo-1-chlor...

Hydrogen bromide Structure

Hydrogen bromide

acetic acid Structure

~%

6-Bromo-1-chloro-2-naphthol Structure

6-Bromo-1-chlor...

Ethanol Structure

N/A Structure

Structure

~%

4-(Phenylamino)-1,2-naphthalenedione Structure

4-(Phenylamino)...

1-chloro-1-methyl-1H-naphthalen-2-one Structure

1-chloro-1-meth...

Hydrogen bromide Structure

Hydrogen bromide

acetic acid Structure

~%

6-bromo-1-methylnaphthalen-2-ol Structure

6-bromo-1-methy...

4-Bromo-2-naphthalenamine Structure

4-Bromo-2-napht...

~%

4-bromonaphthalen-2-ol Structure

4-bromonaphthal...

N/A Structure

~%

Hydrogen bromide Structure

Hydrogen bromide

4,7-Dibromo-3-hydroxy-2-naphthoic acid Structure

4,7-Dibromo-3-h...

~%

4,5-dibromoisobenzofuran-1,3-dione Structure

4,5-dibromoisob...

4,7,8-tribromo-3-hydroxy-[2]naphthoic acid Structure

4,7,8-tribromo-...

~%

4,5-dibromoisobenzofuran-1,3-dione Structure

4,5-dibromoisob...

3-Hydroxy-2-naphthoic acid Structure

3-Hydroxy-2-nap...

~%

4,5-dibromoisobenzofuran-1,3-dione Structure

4,5-dibromoisob...

Isomerically pure anthra [2, 3-b: 6, 7-b′]-difuran (anti-ADF...

[Niimi, Kazuki; Mori, Hiroki; Miyazaki, Eigo; Osaka, Itaru; Kakizoe, Hayato; Takimiya, Kazuo; Adachi, Chihaya Chemical Communications, 2012 , vol. 48, # 47 p. 5892 - 5894]

Synthesis and Structural Analysis of Oligo (naphthalene-2, 3...

[Motomura, Takahisa; Nakamura, Hideko; Suginome, Michinori; Murakami, Masahiro; Ito, Yoshihiko Bulletin of the Chemical Society of Japan, 2005 , vol. 78, # 1 p. 142 - 146]

Synthesis and Structural Analysis of Oligo (naphthalene-2, 3...

[Motomura, Takahisa; Nakamura, Hideko; Suginome, Michinori; Murakami, Masahiro; Ito, Yoshihiko Bulletin of the Chemical Society of Japan, 2005 , vol. 78, # 1 p. 142 - 146]

Synthesis and Structural Analysis of Oligo (naphthalene-2, 3...

[Motomura, Takahisa; Nakamura, Hideko; Suginome, Michinori; Murakami, Masahiro; Ito, Yoshihiko Bulletin of the Chemical Society of Japan, 2005 , vol. 78, # 1 p. 142 - 146]