Zhurnal mikrobiologii, epidemiologii, i immunobiologii 1991-06-01

[The mitostatic and lymphotoxic action of kemantane and its effect on B-suppressors].

V M Man'ko, B V Pinegin, T B Rudneva, O L Blagonravova, N G Artsimovich, R I Gadzhiev

Index: Zh. Mikrobiol. Epidemiol. Immunobiol. (6) , 63-5, (1991)

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Abstract

The in vivo study of the influence of Kemantan on the growth of endogenous colonies in the spleen of sublethally (6 Gy) irradiated (CBA x C57BL/6J) F1 mice (mitostatic action) and on the capacity of transplanted lymphocytes of CBA mice for suppressing their multiplication (lymphotoxic action) was carried out. Besides the capacity of Kemantan for affecting the induction, formation and functioning of B-suppressors of antibody formation was studied. As revealed in this study, Kemantan in doses of 0.2-200 mg/kg did not produce a mitostatic and lymphotoxic effect and had no influence on the realization of the suppressing action of mature B-suppressors. In doses of 20 and 200 mr/kg Kemantan, injected to donors at the phase of the induction and accumulation of B-suppressors, abolished their formation.