e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521

Purines. VIII. The Aminolysis of Certain Chlorosubstituted Purines1

SR Breshears, SS Wang, SG Bechtolt…

Index: Breshears et al. Journal of the American Chemical Society, 1959 , vol. 81, p. 3789,3790

Full Text: HTML

Citation Number: 23

Abstract

2, 6-Dichloropurine and 2, 6, 8-trichloropurine were treated with a number of nitrogenous bases. The reactions were found to be stepwise with the 6-position being preferentially aminated. In the case of very active aminating agents the stepwise reaction was accomplished by using aqueous solutions of the amine. For complete aminolysis of the less reactive amines it was necessary to employ pressure equipment. The proof of structure of ...

2,6-Dichloropurine Structure

2,6-Dichloropurine

~%

6-morpholin-4-yl-2-(1-piperidyl)-5H-purine Structure

6-morpholin-4-y...

Piperidine Structure

9H-Purine,2-chloro-6-(4-morpholinyl)- Structure

9H-Purine,2-chl...

~%

6-morpholin-4-yl-2-(1-piperidyl)-5H-purine Structure

6-morpholin-4-y...

(2-Chloro-7H-purin-6-yl)-furan-2-ylmethyl-amine Structure

(2-Chloro-7H-pu...

~%

9H-Purin-6-amine,N-(2-furanylmethyl)-2-hydrazinyl- Structure

9H-Purin-6-amin...

9H-Purine,2-chloro-6-(1-piperidinyl)- Structure

9H-Purine,2-chl...

~%

[6-(1-piperidyl)-5H-purin-2-yl]hydrazine Structure

[6-(1-piperidyl...

2,6,8-trichloropurine Structure

2,6,8-trichloro...

Furfurylamine Structure

~%

9H-Purin-6-amine,2,8-dichloro-N-(2-furanylmethyl)- Structure

9H-Purin-6-amin...

2,6,8-trichloropurine Structure

2,6,8-trichloro...

~%

9H-Purine,6-(4-morpholinyl)-2,8-di-1-piperidinyl- Structure

9H-Purine,6-(4-...

Piperidine Structure

2,8-dichloro-6-morpholin-4-yl-7H-purine Structure

2,8-dichloro-6-...

~%

9H-Purine,6-(4-morpholinyl)-2,8-di-1-piperidinyl- Structure

9H-Purine,6-(4-...

9H-Purine,2-chloro-6-(4-morpholinyl)- Structure

9H-Purine,2-chl...

~%

9H-Purine,2-hydrazinyl-6-(4-morpholinyl)- Structure

9H-Purine,2-hyd...

2,6-Dichloropurine Structure

2,6-Dichloropurine

~%

9H-Purine,2-hydrazinyl-6-(4-morpholinyl)- Structure

9H-Purine,2-hyd...

morpholine Structure

2,6,8-trichloropurine Structure

2,6,8-trichloro...

~%

2,8-dichloro-6-morpholin-4-yl-7H-purine Structure

2,8-dichloro-6-...

2,6,8-trichloropurine Structure

2,6,8-trichloro...

~%

9H-Purine-2,8-diamine,N2,N8-bis(2-furanylmethyl)-6-(4-morpholinyl)- Structure

9H-Purine-2,8-d...

Furfurylamine Structure

2,8-dichloro-6-morpholin-4-yl-7H-purine Structure

2,8-dichloro-6-...

~%

9H-Purine-2,8-diamine,N2,N8-bis(2-furanylmethyl)-6-(4-morpholinyl)- Structure

9H-Purine-2,8-d...

2,6,8-trichloropurine Structure

2,6,8-trichloro...

~%

(6,8-dihydrazinyl-5H-purin-2-yl)hydrazine Structure

(6,8-dihydrazin...

9H-Purine,2-chloro-6-(4-morpholinyl)- Structure

9H-Purine,2-chl...

~%

9H-Purine,6-(4-morpholinyl)- Structure

9H-Purine,6-(4-...

2,8-dichloro-6-morpholin-4-yl-7H-purine Structure

2,8-dichloro-6-...

~%

9H-Purine,6-(4-morpholinyl)- Structure

9H-Purine,6-(4-...

2,6,8-trichloropurine Structure

2,6,8-trichloro...

~%

9H-Purine,6-(4-morpholinyl)- Structure

9H-Purine,6-(4-...

2,6-Dichloropurine Structure

2,6-Dichloropurine

~%

9H-Purine,6-(4-morpholinyl)- Structure

9H-Purine,6-(4-...

Piperidine Structure

2,6-Dichloropurine Structure

2,6-Dichloropurine

~%

2,6-bis(1-piperidyl)-5H-purine Structure

2,6-bis(1-piper...

2,6,8-trichloropurine Structure

2,6,8-trichloro...

Dimethylamine hydrochloride Structure

Dimethylamine h...

~%

2,8-dichloro-N,N-dimethyl-5H-purin-6-amine Structure

2,8-dichloro-N,...

Furfurylamine Structure

9H-Purine,2-chloro-6-(1-piperidinyl)- Structure

9H-Purine,2-chl...

~%

9H-Purin-2-amine,N-(2-furanylmethyl)-6-(1-piperidinyl)- Structure

9H-Purin-2-amin...

2,6,8-trichloropurine Structure

2,6,8-trichloro...

~%

N,N-dihexyl-6-morpholin-4-yl-7H-purine-2,8-diamine Structure

N,N-dihexyl-6-m...

Hexylamine Structure

2,8-dichloro-6-morpholin-4-yl-7H-purine Structure

2,8-dichloro-6-...

~%

N,N-dihexyl-6-morpholin-4-yl-7H-purine-2,8-diamine Structure

N,N-dihexyl-6-m...