Chemistry and physics of lipids

Inhibition of human gastric and pancreatic lipases by chiral alkylphosphonates. A kinetic study with 1, 2-didecanoyl-sn-glycerol monolayer

JF Cavalier, S Ransac, R Verger, G Buono

Index: Cavalier, Jean-Francois; Ransac, Stephane; Verger, Robert; Buono, Gerard Chemistry and Physics of Lipids, 1999 , vol. 100, # 1-2 p. 3 - 31

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Citation Number: 29

Abstract

Enantiomerically pure alkylphosphonate compounds RR′ P (O) PNP (R= CnH2n+ 1, R′= OY with Y= Cn′ H2n′+ 1 with n= n′ or n≠ n′; PNP= p-nitrophenoxy) noted (RY), mimicking the transition state occurring during the carboxyester hydrolysis were synthesized and investigated as potential inhibitors of human gastric lipase (HGL) and human pancreatic lipase (HPL). The inhibitory properties of each enantiomer have been tested with the ...