Chemistry and physics of lipids

Inhibition of human gastric and pancreatic lipases by chiral alkylphosphonates. A kinetic study with 1, 2-didecanoyl-sn-glycerol monolayer

JF Cavalier, S Ransac, R Verger, G Buono

文献索引：Cavalier, Jean-Francois; Ransac, Stephane; Verger, Robert; Buono, Gerard Chemistry and Physics of Lipids, 1999 , vol. 100, # 1-2 p. 3 - 31

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被引用次数: 29

摘要

Enantiomerically pure alkylphosphonate compounds RR′ P (O) PNP (R= CnH2n+ 1, R′= OY with Y= Cn′ H2n′+ 1 with n= n′ or n≠ n′; PNP= p-nitrophenoxy) noted (RY), mimicking the transition state occurring during the carboxyester hydrolysis were synthesized and investigated as potential inhibitors of human gastric lipase (HGL) and human pancreatic lipase (HPL). The inhibitory properties of each enantiomer have been tested with the ...