Antimicrobial Agents and Chemotherapy 2009-03-01

Oral and parenteral therapeutic options for outpatient urinary infections caused by enterobacteriaceae producing CTX-M extended-spectrum beta-lactamases.

Vidhya Prakash, James S Lewis, Monica L Herrera, Brian L Wickes, James H Jorgensen

Index: Antimicrob. Agents Chemother. 53 , 1278-80, (2009)

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Abstract

Effective therapeutic options are needed for community-onset urinary tract infections due to Escherichia coli strains that produce CTX-M extended-spectrum beta-lactamases. We examined 46 urinary isolates producing CTX-M against several oral or long-acting parenteral antimicrobial agents. Approximately 90% were susceptible to fosfomycin and to a combination of cefdinir plus amoxicillin-clavulanate. All were susceptible to ertapenem.