Comparison of azabicyclic esters and oxadiazoles as ligands for the muscarinic receptor

BS Orlek, FE Blaney, F Brown, MSG Clark…

Index: Orlek, Barry S.; Blaney, Frank E.; Brown, Frank; Clark, Michael S. G.; Hadley, Michael S.; et al. Journal of Medicinal Chemistry, 1991 , vol. 34, # 9 p. 2726 - 2735

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Citation Number: 200

Abstract

The link between the cognitive deficit associated with Alzheimer type dementia and the loss of cholinergic function in the disease provides a basis for examining muscarinic agonists as potential therapeutic agents. This paper describes the design and synthesis of novel azabicyclic methyl esters as ligands for the muscarinic receptor. Replacement of the methyl ester by a 3-methyl-1, 2, 4-oxadiazole ring produces potent metabolically more stable ...