Comparison of azabicyclic esters and oxadiazoles as ligands for the muscarinic receptor

BS Orlek, FE Blaney, F Brown, MSG Clark…

文献索引：Orlek, Barry S.; Blaney, Frank E.; Brown, Frank; Clark, Michael S. G.; Hadley, Michael S.; et al. Journal of Medicinal Chemistry, 1991 , vol. 34, # 9 p. 2726 - 2735

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被引用次数: 200

摘要

The link between the cognitive deficit associated with Alzheimer type dementia and the loss of cholinergic function in the disease provides a basis for examining muscarinic agonists as potential therapeutic agents. This paper describes the design and synthesis of novel azabicyclic methyl esters as ligands for the muscarinic receptor. Replacement of the methyl ester by a 3-methyl-1, 2, 4-oxadiazole ring produces potent metabolically more stable ...