Substituent variation in azabicyclic triazole-and tetrazole-based muscarinic receptor ligands

SM Jenkins, HJ Wadsworth, S Bromidge…

Index: Jenkins; Wadsworth; Bromidge; Orlek; Wyman; Riley; Hawkins Journal of Medicinal Chemistry, 1992 , vol. 35, # 13 p. 2392 - 2406

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Citation Number: 77

Abstract

The effect of variation of the 1-azabicyclic substituent on the novel 1, 2, 3-triezol-4yl-, 1, 2, 4triezol-l-y1-, tetrazold-yl-, and tetrezol-2-yl-based muscarinic receptor ligands has been studied, and the em-azabicyclic [2.2. l] heptr3-y1 substituent waa found to give the most potent and efficacious compounds. In addition, variation of the second substituent on 1, 2, 4- triazol-l-y1-and tetrazol-2-yl-based muscarinic receptor ligands has yielded a series of ...