Organic & Biomolecular Chemistry 2012-04-21

Efficient [5 + 1]-strategy for the assembly of 1,8-naphthyridin-4(1H)-ones by domino amination/conjugate addition reactions of 1-(2-chloropyridin-3-yl)prop-2-yn-1-ones with amines.

Viktor O Iaroshenko, Ingo Knepper, Muhammad Zahid, Rene Kuzora, Sergii Dudkin, Alexander Villinger, Peter Langer

Index: Org. Biomol. Chem. 15th ed., 10 , 2955-2959, (2012)

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Abstract

A facile synthetic approach for the synthesis of 1,8-naphthyridine-4(1H)-one derivatives via a catalyst free and Pd-supported tandem amination sequence is developed and described. In a case of aliphatic amines reaction proceeds in a catalyst free mode, however anilines demand Pd-supported reaction conditions.This journal is © The Royal Society of Chemistry 2012