Yao xue xue bao = Acta pharmaceutica Sinica 2003-04-01

[Synthesis and antibacterial activity of pyridonecarboxylic acid derivatives containing 2-methyl-5-nitroimidazol].

Fa-qing Ye, Li Chen, Jin-min Huang

Index: Yao Xue Xue Bao 38(4) , 260-3, (2003)

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Abstract

To study the synthesis and antibacterial activity of pyridonecarboxylic acid derivatives containing 2-methyl-5-nitroimidazol.Pyridonecarboxylic acid derivatives containing 2-methyl-5-nitroimidazol were synthesized primarily from 2-methyl-5-nitroimidazol, norfloxacin, ciprofloxacin, enoxacin via nucleophilic substitution and esterification. The antibacterial activity of the nine target compounds were tested.Nine new compounds were synthesized (IIa-c and IIIa-f). The structure of the title compounds were identified by 1HNMR, MS as well as elementary analysis.Compounds IIa, IIb and IIc showed antibacterial activity, and were worth further studying.