Helvetica chimica acta

An Improved and Versatile Method for the Rapid Synthesis of Aryldihydrobenzofuran Systems by a Boron Tribromide??Mediated Cyclization Reaction

R Detterbeck, M Hesse

Index: Detterbeck, Richard; Hesse, Manfred Helvetica Chimica Acta, 2003 , vol. 86, # 2 p. 343 - 360

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Citation Number: 15

Abstract

Abstract Boron tribromide is presented as a highly reactive reagent that simultaneously allows the demethylation and fully diastereoselective cyclization of different precursor molecules, obtained by an aldol-type reaction, to a series of hydroxylated aryldihydrobenzofuran systems in racemic form. The latter are often found as key structures in natural compounds of different classes. Syntheses of educts, which mainly took ...