Eksperimental'naia i klinicheskaia farmakologiia 2012-01-01

[Clinical efficiency of reamberin - cycloferon combination in treatment of hepatic cirrhosis associated with chronic HCV infection].

V M Frolov, Ia A Sotskaia, O V Kruglova

Index: Eksp. Klin. Farmakol. 75(8) , 34-8, (2012)

Full Text: HTML

Abstract

The clinical efficiency of a reamberin and cycloferon combination for the treatment of hepatic cirrhosis (HC) associated with chronic HCV infection has been studied. Immunological investigation of patients carried out before the treatment revealed a significant increase in the level of proinflammatory cytokines (CK) in serum, whereas the level of anti-inflammatory CK changed rather insignificantly. Use of the reamberin - cycloferon combination provided faster clinical-biochemical remission and, in respect of the pathogenetic state, ensured normalization of the CK profile in the blood. Based on these data, it can be considered as pathogenetically proved and clinically feasible and promising to use the reamberin - cycloferon combinations for a complex treatment of patients with HC associated with chronic HCV-infection.