Tetrahedron

A fluorous Mukaiyama coupling reagent for a concise condensation reaction: utility of medium-fluorous strategy

…, Y Kurata, Y Kunda, A Miyazaki, J Matsui, S Nakamura…

Index: Sugiyama, Yuya; Kurata, Yuki; Kunda, Yoko; Miyazaki, Atsushi; Matsui, Junko; Nakamura, Shuichi; Hamamoto, Hiromi; Shioiri, Takayuki; Matsugi, Masato Tetrahedron, 2012 , vol. 68, # 20 p. 3885 - 3892

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Citation Number: 14

Abstract

The entire study of condensation reactions using various fluorous Mukaiyama reagents, including a novel medium-fluorous strategy, is described. A Mukaiyama reagent bearing a medium-fluorous content tag, between 40 and 60% fluorine by weight, was prepared and examined in ester and amide-forming condensation reactions. At the end of the reactions, the fluorous pyridone by-product was effectively separated from non-fluorous components ...

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