Chemical Communications 2009-09-28

Screening for reactive metabolites using electro-optical arrays featuring human liver cytosol and microsomal enzyme sources and DNA.

Linlin Zhao, John B Schenkman, James F Rusling

Index: Chem. Commun. (Camb.) (36) , 5386-8, (2009)

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Abstract

We demonstrate for the first time the combination of human liver cytosol and microsomal enzyme sources into an electro-optical array to screen for reactive metabolites produced in multi-enzyme metabolic processes.