Journal of heterocyclic chemistry

Decarboxylation in the synthesis of 4??alkyl??, 4??alkenyl??and 4??acylpyrimidines

G Herstad, T Benneche

Index: Herstad, Gunnar; Benneche, Tore Journal of Heterocyclic Chemistry, 2003 , vol. 40, # 2 p. 219 - 224

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Citation Number: 11

Abstract

Abstract Decarboxylation of allylic esters of 4-carboxypyrimidines in toluene at 111 C in the presence of a Pd (0) catalyst, gives a mixture of a 4-alkenylpyrimidine and a pyrimidine unsubstituted in the 4-position. If the decarboxylation is carried out in the presence of benzaldehyde, then benzaldehyde is added to the 4-position. Decarboxylation of 4- carboxypyrimidines in the presence of different electrophiles, results in incorporation of ...