Organic letters

Synthesis of 3-acylindoles by palladium-catalyzed acylation of free (N–H) indoles with nitriles

TS Jiang, GW Wang

Index: Jiang, Tao-Shan; Wang, Guan-Wu Organic Letters, 2013 , vol. 15, # 4 p. 788 - 791

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Citation Number: 45

Abstract

An efficient palladium-catalyzed synthesis of 3-acylindoles using free (N–H) indoles and nitriles has been developed. The acylation reaction proceeded well under the Pd (OAc) 2/2, 2′-bipyridine system and with d-(+)-camphorsulfonic acid as the additive. A possible mechanism involving carbopalladation of nitriles and subsequent hydrolysis of ketimines is proposed.