Izvestiia Akademii nauk. Seriia biologicheskaia / Rossiiskaia akademiia nauk 1994-01-01

[The stacking interaction of antibiotics of the pyrimido[5,4-e]-1,2,4-triazine series with purines].

V L Antonovskiĭ

Index: Izv. Akad. Nauk Ser. Biol. (1) , 145-7, (1994)

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Abstract

The changes in the PMR spectra of purine bases added to aqueous solutions (D2O) of antibiotics of the pyrimido[5,4-e]-1,2,4-triazine type, reumycin and xanthotricin as well as the changes in the PMR indicate formation of heteroassociates with batch structure as a result of stacking interaction. Chemotherapeutic effect of the antibiotics is explained by their intercalation into the batches of the nucleic acids bases, which violates their functioning.