Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 1990-06-01

Mutation induction in Chinese hamster lung V79 cells by five alk-2-enals produced by lipid peroxidation.

R Canonero, A Martelli, U M Marinari, G Brambilla

Index: Mutat. Res. 244(2) , 153-6, (1990)

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Abstract

Five alk-2-enals--pent-2-enal, hex-2-enal, hept-2-enal, oct-2-enal and non-2-enal--produced by lipid peroxidation were tested for mutagenic activity in V79 Chinese hamster cells. At concentrations ranging from 0.003 to 0.3 mM all 5 alk-2-enals induced a dose-dependent increase in the frequency of 6-thioguanine-resistant mutants, and their mutagenic potency was found to increase with the length of the carbon chain. In contrast, only hept-2-enal produced a statistically significant increase in the number of mutations to ouabain resistance.