Chemical Communications 2009-07-07

Enabling olefin metathesis on proteins: chemical methods for installation of S-allyl cysteine.

Justin M Chalker, Yuya A Lin, Omar Boutureira, Benjamin G Davis

Index: Chem. Commun. (Camb.) (25) , 3714-6, (2009)

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Abstract

Multiple, complementary methods are reported for the chemical conversion of cysteine to S-allyl cysteine on protein surfaces, a useful transformation for the exploration of olefin metathesis on proteins.