Journal of Natural Products 2010-11-29

A short synthesis of the triazolopyrimidine antibiotic essramycin.

Ugo Battaglia, Christopher J Moody

Index: J. Nat. Prod. 73(11) , 1938-9, (2010)

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Abstract

A short synthesis of the 1,2,4-triazolo[1,5-a]pyrimidine antibiotic essramycin is described involving condensation of aminoguanidine with ethyl benzoylacetate to give an amino-1,2,4-triazole, followed by condensation with ethyl acetoacetate to form the pyrimidone ring.