Dual-action agents 5a–f and 12a–f, a β-lactam antibiotic combined with a cytotoxic agent, mitozolomide (Meto) or temozolomide (Temo), were synthesised. The antibacterial activity (MICs) of the dual-action agents has been determined against a panel of bacteria including several β-lactamase producing strains. The tests showed 5a–f active against the non-β- lactamase producing methicillin sensitive Staphylococcus aureus (MSSA) strains, ...
