Synthesis and antibacterial activity of dual-action agents of a β-lactam antibiotic with cytotoxic agent mitozolomide or temozolomide

Y Wang, P Lambert, L Zhao, D Wang

文献索引：Wang, Yongfeng; Lambert, Peter; Zhao, Linxiang; Wang, Danni European Journal of Medicinal Chemistry, 2002 , vol. 37, # 4 p. 323 - 332

全文：HTML全文

被引用次数: 17

摘要

Dual-action agents 5a–f and 12a–f, a β-lactam antibiotic combined with a cytotoxic agent, mitozolomide (Meto) or temozolomide (Temo), were synthesised. The antibacterial activity (MICs) of the dual-action agents has been determined against a panel of bacteria including several β-lactamase producing strains. The tests showed 5a–f active against the non-β- lactamase producing methicillin sensitive Staphylococcus aureus (MSSA) strains, ...