Organic Letters 2012-04-20

A model study for constructing the DEF-benzoxocin ring system of menogaril and nogalamycin via a reductive Heck cyclization.

Ruogu Peng, Michael S VanNieuwenhze

Index: Org. Lett. 14(8) , 1962-5, (2012)

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Abstract

A novel reductive Heck cyclization approach was developed in order to construct a model DEF-benzoxocin ring system that is present in nogalamycin, menogaril, and related anthracycline antitumor antibiotics.© 2012 American Chemical Society