Food and Chemical Toxicology 2012-06-01

Comparison of murine anorectic responses to the 8-ketotrichothecenes 3-acetyldeoxynivalenol, 15-acetyldeoxynivalenol, fusarenon X and nivalenol

Wenda Wu, Brenna M. Flannery, Yoshiko Sugita-Konishi, Maiko Watanabe, Haibin Zhang, James J. Pestka

Index: Food Chem. Toxicol. 50(6) , 2056-61, (2012)

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Abstract

Highlights ► We compare the anorectic effects of 3-ADON, 15- ADON, NIV, FX to those of DON. ► Like DON, 3-ADON and 15-ADON induce transient anorexia. ► FX and NIV induce much longer, persistent anorectic effects than DON or the ADONs. ► IP exposures to trichothecenes provoke stronger anorectic responses than do oral exposures.