Stereoselective syntheses of substituted 5, 6-dihydro-2 (1H)-pyridinones in polyphosphate media

…, U Grabowska, A Fallah, T Walsgrove…

Index: Marson; Grabowska; Fallah; Walsgrove; Eggleston; Baures Journal of Organic Chemistry, 1994 , vol. 59, # 2 p. 291 - 296

Full Text: HTML

Citation Number: 37

Abstract

b-lactams have been synthesized with excellent stereocontrol of substituents by condensing 3-alkenamides with aryl aldehydes in polyphosphoric ester. The scope of the condensation of 3-alkenamides with aryl aldehydes in several phosphate media is examined, and a rationale is proposed regarding y-lactam versus 8-lactam formation.