Organic letters

Large-scale, protection-free synthesis of Se-adenosyl-L-selenomethionine analogues and their application as cofactor surrogates of methyltransferases

IR Bothwell, M Luo

Index: Bothwell, Ian R.; Luo, Minkui Organic Letters, 2014 , vol. 16, # 11 p. 3056 - 3059

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Citation Number: 11

Abstract

S-Adenosyl-l-methionine (SAM) analogues have previously demonstrated their utility as chemical reporters of methyltransferases. Here we describe the facile, large-scale synthesis of Se-alkyl Se-adenosyl-l-selenomethionine (SeAM) analogues and their precursor, Se-