Characterization of an endogenous factor controlling the cell cycle of complex tissues

…, K Jaffe, M Cornwall, W Tramontano

Index: Lynn, David G.; Jaffe, Keeve; Cornwall, Michael; Tramontano, William Journal of the American Chemical Society, 1987 , vol. 109, # 19 p. 5858 - 5859

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Citation Number: 18

Abstract

The study and characterization of factors called chalones which are capable of regulating specific cellular arrest in complex tissues has been ongoing since their discovery in 1960.'Their obvious potential chemotherapeutic use and more recently their potential involvement in circadian rhythms2s3 has stimulated continual interest in these factors. Trigonelline, N-methylnicotinic acid, became the first structurally defined substance ...