Synthesis and in vivo evaluation of N-ethylamino-2-oxo-1, 2-dihydro-quinoline-3-carboxamide for inhibition of intestinal tumorigenesis in APCMin/+ mice

G Pathuri, Q Li, A Mohammed, H Gali, JT Pento…

Index: Pathuri, Gopal; Li, Qian; Mohammed, Altaf; Gali, Hariprasad; Pento, J. Thomas; Rao, Chinthalapally V. Bioorganic and Medicinal Chemistry Letters, 2014 , vol. 24, # 5 p. 1380 - 1382

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Citation Number: 5

Abstract

Abstract A selective KGFR tyrosine kinase inhibitor, N-ethylamino-2-oxo-1, 2-dihydro- quinoline-3-carboxamide, was synthesized and its possible inhibitory effects on the development of colon polyps and colorectal tumors was examined in APC Min/+ mice, a mouse model of human intestinal familial adenomatous polyposis. The present study shows for the first time that a dietary administration of a selective KGFR tyrosine kinase inhibitor ...