Structure–activity relationships studies of the anti-angiogenic activities of linomide

J Shi, Z Xiao, MA Ihnat, C Kamat, B Pandit, Z Hu…

Index: Shi, Jiandong; Xiao, Zili; Ihnat, Michael A.; Kamat, Chandrashekhar; Pandit, Bulbul; Hu, Zhigen; Li, Pui-Kai Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 6 p. 1187 - 1189

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Citation Number: 29

Abstract

The synthesis and anti-angiogenic activities of linomide and its analogues are reported. Three of the analogues are 3.3–69 times more potent than linomide at inhibiting blood vessel formation in the CAM angiogenesis assay. These compounds possessed considerable anti-proliferative activity against isolated HUVEC cells with no activity against epithelial-derived prostate tumor cells.

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Structure–activity relationships studies of the anti-angioge...

[Bioorganic and Medicinal Chemistry Letters, , vol. 13, # 6 p. 1187 - 1189]