Structure–activity relationships studies of the anti-angiogenic activities of linomide

J Shi, Z Xiao, MA Ihnat, C Kamat, B Pandit, Z Hu…

文献索引：Shi, Jiandong; Xiao, Zili; Ihnat, Michael A.; Kamat, Chandrashekhar; Pandit, Bulbul; Hu, Zhigen; Li, Pui-Kai Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 6 p. 1187 - 1189

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被引用次数: 29

摘要

The synthesis and anti-angiogenic activities of linomide and its analogues are reported. Three of the analogues are 3.3–69 times more potent than linomide at inhibiting blood vessel formation in the CAM angiogenesis assay. These compounds possessed considerable anti-proliferative activity against isolated HUVEC cells with no activity against epithelial-derived prostate tumor cells.

85870-47-9

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Structure–activity relationships studies of the anti-angioge...

[Bioorganic and Medicinal Chemistry Letters, , vol. 13, # 6 p. 1187 - 1189]