Tetrahedron Letters

Palladium-catalysed cross-coupling of 2-trimethylsilylpyridine with aryl halides

S Napier, SM Marcuccio, H Tye, M Whittaker

Index: Napier, Spencer; Marcuccio, Sebastian M.; Tye, Heather; Whittaker, Mark Tetrahedron Letters, 2008 , vol. 49, # 44 p. 6314 - 6315

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Citation Number: 19

Abstract

Palladium-catalysed cross-coupling of 2-trimethylsilylpyridine with aryl halides in the presence of stoichiometric silver (I) oxide, and catalytic TBAF allows the rapid preparation of the corresponding pyridin-2-ylaryl compounds in moderate to good yields under mild thermal conditions.

~46%

~74%

~69%

~20%

~40%

~47%

~64%

~44%

~6%

~50%

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