FEBS Letters 2013-03-01

Vimentin is a component of a complex that binds to the 5'-UTR of human heme-regulated eIF2α kinase mRNA and regulates its translation.

Sangeeta Chatterjee, Amaresh C Panda, Sunil K Berwal, R K Sreejith, Charu Ritvika, Vasudevan Seshadri, Jayanta K Pal

Index: FEBS Lett. 587(5) , 474-80, (2013)

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Abstract

The human heme-regulated eIF2α kinase, also called the human heme-regulated inhibitor (hHRI) is significantly up-regulated particularly at the level of translation during stress. In this report we show that during lead-stress, the regulation of hHRI mRNA translation is mediated through its 5'-untranslated region (UTR) that interacts with specific trans-acting factors. Further, vimentin has been identified as one of the trans-acting factors that contribute to this regulation.Copyright © 2013 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.