Dual protein farnesyltransferase-geranylgeranyltransferase-I inhibitors as potential cancer chemotherapeutic agents

SJ deSolms, TM Ciccarone, SC MacTough…

Index: Journal of Medicinal Chemistry, , vol. 46, # 14 p. 2973 - 2984

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Citation Number: 55

Abstract

... Journal of Medicinal ... Departments of Medicinal Chemistry and Cancer Research, Merck Research Laboratories, West Point, Pennsylvania 19486, Department ... Laboratories, Rahway, New Jersey 07065, and Department of Biochemistry, Duke University Medical Center, Durham ...

3-Aminopyrrolidinone farnesyltransferase inhibitors: design ...

[Bell, Ian M.; Gallicchio, Steven N.; Abrams, Marc; Beese, Lorena S.; Beshore, Douglas C.; Bhimnathwala, Hema; Bogusky, Michael J.; Buser, Carolyn A.; Culberson, J. Christopher; Davide, Joseph; Ellis-Hutchings, Michelle; Fernandes, Christine; Gibbs, Jackson B.; Graham, Samuel L.; Hamilton, Kelly A.; Hartman, George D.; Heimbrook, David C.; Homnick, Carl F.; Huber, Hans E.; Huff, Joel R.; Kassahun, Kelem; Koblan, Kenneth S.; Kohl, Nancy E.; Lobell, Robert B.; Lynch Jr., Joseph J.; Robinson, Ronald; Rodrigues, A. David; Taylor, Jeffrey S.; Walsh, Eileen S.; Williams, Theresa M.; Zartmant, C. Blair Journal of Medicinal Chemistry, 2002 , vol. 45, # 12 p. 2388 - 2409]

A fluorine scan of the phenylamidinium needle of tricyclic t...

[Olsen, Jacob; Seiler, Paul; Wagner, Bjoern; Fischer, Holger; Tschopp, Thomas; Obst-Sander, Ulrike; Banner, David W.; Kansy, Manfred; Mueller, Klaus; Diederich, Francois Organic and Biomolecular Chemistry, 2004 , vol. 2, # 9 p. 1339 - 1352]

A fluorine scan of the phenylamidinium needle of tricyclic t...

[Organic and Biomolecular Chemistry, , vol. 2, # 9 p. 1339 - 1352]

Asymmetric synthesis of α, α-diaryl and α-aryl-α-heteroaryl ...

[Tetrahedron Letters, , vol. 42, # 41 p. 7173 - 7176]