Dual protein farnesyltransferase-geranylgeranyltransferase-I inhibitors as potential cancer chemotherapeutic agents

SJ deSolms, TM Ciccarone, SC MacTough…

文献索引：Journal of Medicinal Chemistry, , vol. 46, # 14 p. 2973 - 2984

被引用次数: 55

摘要

... Journal of Medicinal ... Departments of Medicinal Chemistry and Cancer Research, Merck Research Laboratories, West Point, Pennsylvania 19486, Department ... Laboratories, Rahway, New Jersey 07065, and Department of Biochemistry, Duke University Medical Center, Durham ...

153556-42-4

4-溴-3-氟苯甲酸

3-Aminopyrrolidinone farnesyltransferase inhibitors: design ...

[Bell, Ian M.; Gallicchio, Steven N.; Abrams, Marc; Beese, Lorena S.; Beshore, Douglas C.; Bhimnathwala, Hema; Bogusky, Michael J.; Buser, Carolyn A.; Culberson, J. Christopher; Davide, Joseph; Ellis-Hutchings, Michelle; Fernandes, Christine; Gibbs, Jackson B.; Graham, Samuel L.; Hamilton, Kelly A.; Hartman, George D.; Heimbrook, David C.; Homnick, Carl F.; Huber, Hans E.; Huff, Joel R.; Kassahun, Kelem; Koblan, Kenneth S.; Kohl, Nancy E.; Lobell, Robert B.; Lynch Jr., Joseph J.; Robinson, Ronald; Rodrigues, A. David; Taylor, Jeffrey S.; Walsh, Eileen S.; Williams, Theresa M.; Zartmant, C. Blair Journal of Medicinal Chemistry, 2002 , vol. 45, # 12 p. 2388 - 2409]

A fluorine scan of the phenylamidinium needle of tricyclic t...

[Olsen, Jacob; Seiler, Paul; Wagner, Bjoern; Fischer, Holger; Tschopp, Thomas; Obst-Sander, Ulrike; Banner, David W.; Kansy, Manfred; Mueller, Klaus; Diederich, Francois Organic and Biomolecular Chemistry, 2004 , vol. 2, # 9 p. 1339 - 1352]

A fluorine scan of the phenylamidinium needle of tricyclic t...

[Organic and Biomolecular Chemistry, , vol. 2, # 9 p. 1339 - 1352]

Asymmetric synthesis of α, α-diaryl and α-aryl-α-heteroaryl ...

[Tetrahedron Letters, , vol. 42, # 41 p. 7173 - 7176]