Bioorganic & Medicinal Chemistry Letters 2010-11-01

Bernthsen synthesis, antimicrobial activities and cytotoxicity of acridine derivatives.

Mehul M Patel, Mimansha D Mali, Saurabh K Patel

Index: Prep Biochem Biotechnol. 43(1) , 1-21, (2013)

Full Text: HTML

Abstract

The condensation reaction of diphenylamine with 2-oxo-2H-(substituted chromen)-4-yl acetic acid in presence of anhydrous zinc chloride afford 4-(acridine-9-ylmethyl)-2H-(substituted chromen)-2-one. The synthesized compounds were characterized by spectral studies and elemental analysis and screened for their in vitro antibacterial activity against Staphylococcus aureus, Staphylococcus pyogenes (gram +ve), Escherichia coli, Pseudomonas aeruginosa (gram -ve) and antifungal activity against Aspergillus niger and anticancer activity (HL-60, Hep-2 & HEK293T) by MTT assay. Chloro substituted compounds showed antimicrobial and anticancer activity with IC(50) values in the low micromolar range.Copyright © 2010. Published by Elsevier Ltd.