Toxicology Letters 2013-06-07

Aberrant activation of M phase proteins by cell proliferation-evoking carcinogens after 28-day administration in rats

Atsunori Yafune, Eriko Taniai, Reiko Morita, Hitomi Hayashi, Kazuhiko Suzuki, Kunitoshi Mitsumori, Makoto Shibutani

Index: Toxicol. Lett. 219(3) , 203-10, (2013)

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Abstract

• This study aimed to identify early prediction markers of carcinogens in rats. • Cellular distribution of cell cycle proteins was analyzed after 28-day treatment. • Cell proliferation-evoking carcinogens induced activation of M phase proteins. • Carcinogens lacking proliferative activity did not have these effects. • Cell proliferation and M phase proteins might functions as an early prediction unit.