An alternative approach for the conversion of aldehydes to terminal alkynes

Z Wang, J Yin, S Campagna, JA Pesti…

Index: Wang, Zhe; Yin, Jianguo; Campagna, Silvio; Pesti, Jaan A.; Fortunak, Joseph M. Journal of Organic Chemistry, 1999 , vol. 64, # 18 p. 6918 - 6920

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Citation Number: 26

Abstract

Efavirenz (Sustiva, DMP 266) is a nonnucleoside reverse transcriptase inhibitor of the HIV-1 virus developed by our company for the treatment of AIDS. This compound demonstrates superior antiretroviral activity and has been approved for use as an anti-HIV agent in the US Our enantioselective synthesis of Efavirenz1 employs cyclopropylacetylene (1), which is expensive and difficult to obtain. The existing preparations of 1 require either 5-chloro-1- ...