Mini-Reviews in Medicinal Chemistry 2006-01-01

Solid-phase synthesis in the twenty-first century.

A Ganesan

Index: Mini Rev. Med. Chem. 6(1) , 3-10, (2006)

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Abstract

Solid-phase synthesis is a powerful tool for achieving high-throughput chemistry. This review discusses recent diverse examples from my group: the solid-phase synthesis of unsymmetrical guanidines, polymer-supported versions of cyclooctadiene and 9-BBN, a triflate-like linker, the synthesis of tetrahydro-beta-carbolines by the acyliminium Pictet-Spengler reaction, and a total synthesis of the antimycobacterial cyclic depsipeptide natural product kahalalide A.