Toxicology 2014-04-06

Astrocytes protect against diazinon- and diazoxon-induced inhibition of neurite outgrowth by regulating neuronal glutathione

Daniella M. Pizzurro, Khoi Dao, Lucio G. Costa

Index: Toxicology 318 , 59-68, (2014)

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Abstract

• The organophosphorus insecticide diazinon (DZ) and its active metabolite diazoxon (DZO) inhibit neurite outgrowth in rat hippocampal neurons. • Both compounds increase oxidative stress in neurons. • Neurite outgrowth inhibition is prevented by antioxidants, including glutathione. • Astrocytes protect against neurite outgrowth inhibition by regulating neuronal glutathione. • Astrocytes depleted of glutathione no longer prevent DZ- or DZO-induced inhibition.